Uncover genetic interactions in Caenorhabditis elegans by RNA interference.

نویسندگان

  • Angelo Fortunato
  • Andrew G Fraser
چکیده

RNA-mediated interference (RNAi) has emerged recently as one of the most powerful functional genomics tools. RNAi has been particularly effective in the nematode worm C. elegans where RNAi has been used to analyse the loss-of-function phenotypes of almost all predicted genes. In this review, we illustrate how RNAi has been used to analyse gene function in C. elegans as well as pointing to some future directions for using RNAi to examine genetic interactions in a systematic manner.

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عنوان ژورنال:
  • Bioscience reports

دوره 25 5-6  شماره 

صفحات  -

تاریخ انتشار 2005